Disclaimer: I don't have any idea if any of these are the best supplements for middle age. I just recently took a bunch of them and thought I'd share my experiences. Do with it what you'd like.

Ibuprofen- Alright, not technically a supplement, but the way I take them it may as well be. Basically, I drop them like breath mints and it was the pace and volume that I chug them that got me thinking about alternatives in the first place. Actually, I didn't think about alternatives at all until people kept bothering me about how many ibuprofen I took. People would say, "Did you just take 10 ibuprofen??? That's bad for you! That will hurt your insert random organ here." To which I say, "That's fine. As soon as my random organ hurts worse than my hip, knee, back, and marriage, I'll change things up." Until then though, it's legal, it's over the counter, and taken in fistfuls it works well enough to get me to tomorrow. I can't say that about anything else in my life.